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Sunday, May 3, 2020 | History

5 edition of Ras-Mapk Signaling on Differentiating Sh-Sy5Y Human Neuroblastoma Cells found in the catalog.

Ras-Mapk Signaling on Differentiating Sh-Sy5Y Human Neuroblastoma Cells

Anna-Karin Olsson

Ras-Mapk Signaling on Differentiating Sh-Sy5Y Human Neuroblastoma Cells

  • 137 Want to read
  • 24 Currently reading

Published by Uppsala Universitet .
Written in English

    Subjects:
  • Pathology,
  • Medical

  • Edition Notes

    SeriesComprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 950
    The Physical Object
    FormatPaperback
    Number of Pages66
    ID Numbers
    Open LibraryOL12854261M
    ISBN 109155447937
    ISBN 109789155447939


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Ras-Mapk Signaling on Differentiating Sh-Sy5Y Human Neuroblastoma Cells by Anna-Karin Olsson Download PDF EPUB FB2

Ras-Mapk Signaling on Differentiating Sh-Sy5Y Human Neuroblastoma Cells book Signaling on Differentiating Sh-Sy5Y Human Neuroblastoma Cells (Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ):. Although they induce growth of many cell types, these factors can act as differentiating agents in SH-SY5Y cells as judged by morphology, reduction of c-myc mRNA Cited by: Alpha and Epsilon, Neurofibromin, and the Ras/MAPK Pathway in Neuroblastoma Differentiation Thus, differentiation in SH-SY5Y cells is characterized by intense, PKC ε -dependent.

AKT/mTOR pharmacologic inhibition sensitizes RAS/MAPK-activated neuroblastoma cells to MEK1/2 inhibitors [abstract]. In: Proceedings of the American Association for Cancer.

Here, we confirm that NGF stimulates SOD2 expression, in TrkA SH-SY5Y cells (this study), adding to observations that NGF induces Ras/MAPK signalling and neuronal differentiation in TrkA SH-SY5Y cells, and suggesting that SOD2 expression in SH-SY5Y Cited by:   Curcumin provoked DNA damage in neuroblastoma cells and up-regulation of GOLPH3 with Golgi dispersal.

(A) IMR, SH-SY5Y and non-tumorigenic control HEK Cited by: 1. SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signalling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is unclear.

To investigate this mechanism, we compared the gene expression profiles in SK-N-SH cells and two subtypes of SH-SY5Y cells (SH-SY5Y-A and SH-SY5Y Cited by: Publisher Summary.

The central importance of the general phenomenon of sensing of external stimuli by cells has been appreciated for a long time, but has truly become a dominant part of.

Neuroblastoma (NB) is an aggressive, relapse-prone infancy tumor of the sympathetic nervous system and is the leading cause of death among preschool age diseases, so the search for. Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, Cited by: 1.

HeLa cells and SH-SY5Y neuroblastoma cells were main-tained in Dulbecco’s Modified Eagle’s Medium supple-mented with 10% fetal bovine serum, 2 mM L-glutamine, units/ml penicillin and μg/ml Streptomycin (GIBCO™, Invitrogen).

In the case of SH-SY5Y. Categories. Baby & children Computers & electronics Entertainment & hobby. There was no FGF8 expression change in the aggregation of other non-ES/EC cells such as human neuroblastoma SH-SY5Y cells, rat glioma C6 cells, and mouse mammary.

Neurotrophins control survival, differentiation and maintenance of neurons and glial cells in the central and peripheral nervous system.

Their biological functions are mediated by two distinct Cited by: 6. Human neuroblastoma SH-SY5Y cells show increased resistance to hyperthermic stress after differentiation, associated with elevated levels of Hsp72 Academic Article Hyaluronan is.

Effects on signaling through the Ras/MAPK pathway were measured using Western blots. Results: UBE4B expression was associated with neuroblastoma differentiation in patient.

These drugs are having neuroprotective roles in both human neuroblastoma SH-SY5Y cells and primary rat mid-brain dopaminergic neuronal cultures toxicity induced by 6-hidroxydopamine.

Cited by: 7. Full text of "DTIC ADA Proceedings of EUROTOXCongress of the European Societies of Toxicology (40th)" See other formats. This is the basic premise of looking at growth factor families, steroid hormones and cytokines, and any commonality or merger of signalling cas- cades in their function as signalling molecules.

Growth Factors and Their Receptors in Cell Differentiation. The region of the human chromosome 22q11 is believed to be involved in diseases caused by chromosomal aberrations. The human TXNRD1 gene is divided into 16 exons spanning.

Accordingly, the involvement of calcium, a likely cell death cause, during transient and prolonged ischemia in human neuroblastoma cell line (SH-SY5Y) was considered, together with its.

(Source: Journal of Biomolecular Screening) A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays Human neuronal cells.

Deciphering the RAS/MAPK signaling pathway in cancer M. Barbacid (Spain) – OECI supported Plenary Symposium: Cancer Immunology (Exchange Hall) Chair: C. Von Kalle. which prevents migration/invasion and vascular infiltration of cancer cells by inhibiting the formyl peptide receptor type 1 activity.

Tutor: Maria Vincenza Carriero Ali Mokhtar Mahmoud Effect of. modulaciÓn de la transducciÓn de la seÑal asociada a receptores tirosina.

on 15 сентября In addition, TGFb signaling through the type I receptor, ALK5, leads to MEK/ERK-dependent induction of MMP9 mRNA in human breast cancer cells (Safina et al. Formation. protein trafficking in neurons editor ANDREW J. BEAN, Ph.D.

Department of Neurobiology and Anatomy The University of Texas Health Science Center at Houston Houston, Texas. L-type Voltage-Gated Calcium Channels in Conditioned Fear: A Genetic and Pharmacological Analysis.

ERIC Educational Resources Information Center. McKinney. Moreover, Se-PC was identified as a potent antiproliferative agent against human melanoma A cells and human breast adenocarcinoma MCF-7 cells. Induction of apoptosis in both. RESULTS: Integrin alpha8beta1 was found to be expressed in the crypt cell population of the human intestine but was absent from differentiating and mature epithelial cells of the villus.

Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines. PubMed Central. Yajima, Ichiro; Kumasaka, Mayuko Y; Naito, Yuji.

The concepts of affinity and efficacy are used to describe the pharmacology of a drug (ligand). Affinity refers to the ability of the drug to bind to its molecular target, and efficacy refers to the ability of a drug to induce a biological response in its molecular target.